A study in primates/human glaucoma patients is underway (~next 2 years).
Randomized clinical trials are not as golden a standard as they seem and methodologically they are designed for human cattle, who do not choose what to consume and do not care to read a Wikipedia page or more about the drug they're taking or its target receptors they have, let alone any research on it.
Thus, in an instruction label for an approved drug you'll see dozens of adverse effects, established in randomized clinical trials, yet close to zero information about the probability of you personally being affected by these adverse effects.
Likewise, there are ~thousands of "biohackers" taking the safe metformin off-label, for "anti-aging" purposes. And any interested individual can choose an experimental treatment, taking all the risks etc.
As per Hippocrates Oath [1]:
1) I swear to fulfill, to the best of my ability and judgment, this covenant:
2) I will apply, for the benefit of the sick, all measures [that] are required
3) I will prevent disease whenever I can, for prevention is preferable to cure.
How would you ensure a physician is employing the best of their ability? By their brain oxygenation level? Or dopamine receptors occupancy in prefrontal "executive" cortex?
Thus ~90% of physicians regularly violate at least 2) and 3) statements of the oath, by not offering the possible experimental treatments in relevant sets&settings.
Randomized clinical trials are not as golden a standard as they seem and methodologically they are designed for human cattle, who do not choose what to consume and do not care to read a Wikipedia page or more about the drug they're taking or its target receptors they have, let alone any research on it. Thus, in an instruction label for an approved drug you'll see dozens of adverse effects, established in randomized clinical trials, yet close to zero information about the probability of you personally being affected by these adverse effects.
Likewise, there are ~thousands of "biohackers" taking the safe metformin off-label, for "anti-aging" purposes. And any interested individual can choose an experimental treatment, taking all the risks etc.
As per Hippocrates Oath [1]: 1) I swear to fulfill, to the best of my ability and judgment, this covenant: 2) I will apply, for the benefit of the sick, all measures [that] are required 3) I will prevent disease whenever I can, for prevention is preferable to cure.
How would you ensure a physician is employing the best of their ability? By their brain oxygenation level? Or dopamine receptors occupancy in prefrontal "executive" cortex? Thus ~90% of physicians regularly violate at least 2) and 3) statements of the oath, by not offering the possible experimental treatments in relevant sets&settings.
[1] https://en.wikipedia.org/wiki/Hippocratic_Oath