[rciorba]

It really depends on the use-case. Async Python is nice for IO-heavy APIs If CPU-heavy workloads are likely, I'd probably look into using go.

In terms of FE, it really depends on the skill-set in the team. I went for Vue over React when we had to have a bunch of backenders whip up a FE simply because it's more opinionated and we didn't want to have to make as many choices when getting started. Also, just rendering HTML on the server side can still get you a long way

For the DB, again, it depends on your use case and what your data-model looks like, but I think a relational DB like postgres is a safe choice 99% of the time. You might need to couple it with something else on occasion (I've reached for elasticsearch more times than I can count)