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by wahern 1260 days ago
> While links between HPV and cervical cancer are quite strong and well-defined, the associations with the other viruses you cite are only correlative.

HPV is merely correlative, as well. That's basically how all endogenous cancers work. With Epstein-Barr Virus the association is quite strong, though the incidence of EBV-induced cancers doesn't seem to be quite as large as HPV--~1% vs 2-3%.

1 comments

HPV isn't correlative, it's causative. Additional co-transformation factors may be required, but it is well understood that E6 and E7 proteins directly lead to tumorigenesis. EBV pathogenic mechanisms are more autocrine and therefore a muddier picture, hence correlative.