PyPy work well with CPython modules but the performance is not that great, with CFFI performance is really good in PyPY, HPy project will change this https://hpyproject.org/
Last I checked, Pypy wasn’t compatible with many important packages in the Python ecosystem. As of a couple years ago, there was no trustworthy, supported package for talking to a Postgres database with Pypy because psycopg2 wasn’t supported.
postgresql can work with psycopg2 but is not the same performance as psycopg2cffi , i will integrate some databases to PyPy, and also HPy project will bring any Cython library to PyPy with basically the same performance or better.