[karl_gluck]

That’s what I thought too, until a friend sent me the paper “Class switch towards non-inflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination” published a few weeks ago:

https://www.science.org/doi/10.1126/sciimmunol.ade2798

From what I can understand, it seems mRNA vaccines can cause a non-inflammatory response to actual infection that prolongs the disease. I’m supportive of vaccination, but that doesn’t mean side effects can’t happen especially with new technology.

[Izkata]

Oh, there's more. Remember all those refutations of claims that it changes your DNA? Pretty much all of them went something like "That's stupid, DNA is converted into RNA, not the other way around!" - meanwhile the people who were concerned about it knew about reverse transcriptase enzyme, and months later a study was published showing it can happen in human liver cells: https://www.mdpi.com/1467-3045/44/3/73

[skiman10]

Okay but not really though right?

https://www.aap.com.au/factcheck/a-swedish-study-did-not-say...

[Izkata]

Yes really, to quote my link:

> PCR on genomic DNA of Huh7 cells exposed to BNT162b2 amplified the DNA sequence unique to BNT162b2. Our results indicate a fast up-take of BNT162b2 into human liver cell line Huh7, leading to changes in LINE-1 expression and distribution. We also show that BNT162b2 mRNA is reverse transcribed intracellularly into DNA in as fast as 6 h upon BNT162b2 exposure.

They showed it actually happening in extracted human liver cells in a lab, not in a live human. That would be the next step. But in the meantime the "genomic DNA" part does sound like it made a permanent change to those cells.

[grey-area]

The researchers say you’re wrong. Read the article linked, and question why you’re being fed conspiracy theories.

[Izkata]

The fact check does not address the sentence I quoted, where they tested the "genomic DNA" and found a match to the mRNA vaccine.

[skiman10]

Two authors of the Lund University study, Associate Professor Yang de Marinis and Professor Magnus Rasmussen, have also released a Q&A in response to the attention their work has generated on social media.

“The results have in many cases been misinterpreted,” they said.

“This study does not investigate whether the Pfizer vaccine alters our genome,” de Marinis confirmed.

Prof Rasmussen also stated: “There is no reason for anyone to change their decision to take the vaccine based on this study.”

The study was conducted in a laboratory on cells in a petri dish, which is not the same as a study on human subjects because “cell lines differ from cells in living organisms,” Rasmussen wrote.

Dr Parry also said the Huh7 cell line is very different from healthy human cells.

“Huh-7 is an immortal, tumorigenic cell line,” he said. “This is barely an appropriate system to make any claims of in healthy persons.”

https://www.aap.com.au/factcheck/a-swedish-study-did-not-say...