[CadmiumYellow]

It's funny hearing people debate this topic on HN where the community skews heavily male. The vast majority of women have experienced both of these states of mind and in fact do so on a monthly basis. Three weeks out of the month I get hungry, I eat, I get full, and I don't feel hungry again or think about food at all for hours. You could put a cupcake in front of my face when I was full and I wouldn't even look at it. It requires zero effort to behave this way. Yet during that fourth week I get a constant gnawing feeling in my stomach that never goes away except in the first few minutes after eating something (usually simple carbs). I think about food nearly every minute of the day. Then one day it's like a switch flips and I'm back to having a perfectly normal appetite and satiety signals. It's an excellent lesson in how we're all at the mercy of our biology to some extent.

[Auracle]

I’m a male with hormonal issues and I’ve also taken growth hormone peptides that make you ridiculously hungry. I’m no stranger to how hormones can affect our bodies. All I’m saying is that the type of satiety you get on semaglutide isn’t natural and I’ve never felt it before in my life.

[CadmiumYellow]

Oh I definitely believe you on that. I haven't taken semaglutide myself but from what I've read it seems to increase satiety by slowing digestion, which is why it has nausea as a side effect, and I can't imagine that that's the same as the normal feeling of satiety you get from eating reasonable amounts. Did it make you less hungry in a sick way rather than a neutral way, maybe?