[carrotcarrot]

> Sure. If they were otherwise identical, that'd be a good point, but they're not.

You can say the same of opium, heroin, morphine, oxycodone, fentanyl, and Naloxone. Many of which have had i ical trials done and all of which are abused and addictive.

I simply don't trust clinical trials by large pharmaceutical companies any longer.

[ceejayoz]

> You can say the same of opium, heroin, morphine, oxycodone, fentanyl, and Naloxone. Many of which have had i ical trials done and all of which are abused and addictive.

Cocaine isn't a viable weight-loss drug because its downsides outweigh the benefits. The downsides of semaglutide and tirzepatide are nothing like that of cocaine, and thus the calculus works out better for them.

> You can say the same of opium, heroin, morphine, oxycodone, fentanyl, and Naloxone.

Setting aside the fact that including naloxone in that list is a bit bizarre - it counteracts the rest of the list, everyone should have some in their first aid kit - those medications have benefits that make them sometimes appropriate clinically. (Similarly, cocaine is used medically and in a very controlled fashion in rare cases, like persistent bad nosebleeds.)

[kens]

You say that Naloxone is abused and addictive? That is completely wrong. Naloxone has no addictive potential and has no potential for abuse. I think you have it confused with something else.

Ref: https://www.asam.org/docs/default-source/public-policy-state...