Not if you suffer from RSI and you want to use as few key strokes as possible. I really don't understand this trend towards minimalist keyboards. I want more keys, not fewer.
I mean, a pianist also doesn't put everything on their home row.
Funny, RSI of a different kind is what pushed me to a minimalist keyboard. I pay the cost of increased complexity to avoid the strain of reaching distant keys.
You can also get most of this configuration-free in Gnome. [Super] key switches to a spotlight context; one alphabetic letter focuses the most frequently used app with that prefix; and [Enter] key launches it without prompt.
I mean, a pianist also doesn't put everything on their home row.