[sowbug]

The human body rapidly develops tolerance to tryptamine-based psychedelics (i.e., most of the ones being discussed here). In general, if you take a tryptamine, then taking more won't do anything for at least a couple weeks. (Tolerance isn't all-or-nothing; even if a person has developed it, it's still possible to get a small response with a gigantic dose.)

But even if there were no such thing as tolerance, psychedelics aren't pleasant in the day-in-day-out way that a beer after work can be, or that I imagine an opioid would be. They require far too much emotional work. It's typical to take a moderate mushroom dose, and then spend a month or two "integrating" the experience (i.e., figuring out what the heck all those insights mean).