[snackwalrus]

In my personal experience marijuana only makes depression worse. It can make it more bearable in the moment and treat minor anhedonia, but at least for me it only bolsters my unhealthy habits which in turn makes the depression worse. I don't think there's any evidence that it can lead to long term remission. It's the neuroplasticity provided by psilocybin and ketamine that really helps.

I think psilocybin is promising, but doing it when you're depressed can put you in terrifyingly bad places. I think in the long term psilocybin and ketamine will both end up being valuable tools in combating treatment resistant depression. My guess would be that psilocybin will be used more in clinical settings with a guide and ketamine will be something you can do at home and talk about with a therapist later.