[the_af]

I don't think there is a "best" way, in my biased opinion package management for Python is terrible. It works for trivial cases but if you do anything serious it will get unmanageable fast.

Everyone will tell you of the "best" (i.e. their favorite) way to handle packages and dependencies. Usually mixed with some sandbox framework. Everything will be broken in some way: nonstandard, convoluted, too slow, cannot handle corner cases, or just way too difficult to understand. Even those labeled "for humans". Everyone will agree the situation is a mess "except for this one way that works": never trust that way, it doesn't really work past trivial cases.

Of course this is just my experience. But I feel after years of battling with Python and trying different things, I've earned the right to say this.