[russdill]

Given that European epidemics literally decimated the native population and the military marched many of the remaining natives to reservations that is the reality that most settlers encountered.

[throwaway6734]

The spread of disease was guaranteed to happen sooner or later. Europe and the middle east went through the same thing, just earlier in time

[idontwantthis]

Not nearly as bad in Europe. The Black Death killed 1/3. Pandemics may have killed 95% in America.

[throwaway6734]

Other pandemics were raging across Europe for the thousand years before that. For example, the Antonine plague and plague of Justinian