I dunno if I agree with this premise. Some comforts are illusionary but others are not, and once you lose them they are gone, and you will forever live in discomfort.
It may be uncomfortable, but you will be free. Taken to the extreme, it grants you a sort of freedom that can't be taken away. You can't compel a man who has nothing they're not willing to give up.
An example from my life is that I'm very hard to bully/persuade to let things go/get to accept bad decisions. Usually, the impetus behind shutting up and going along is that speaking up will have ramifications on one's career. However, I have MS, which means I had to come to terms with possibly losing my career randomly no matter what I say or do. So it's not really something that can be held over me anymore.
I'm way more stubborn post diagnosis because I promise you (whoever you are) are way less scary than the fact that I might wake up and never walk again.
In my life this manifests through a willingness to speak up for those lower on the totem pole, to call people out on being manipulative assholes, and a willingness to take bolder decisions because I've been through worse, so come at me, bro.
I know several people who live in pain every day due to their back, one cannot sit basically at all, and they all must constantly change position to manage the pain.
Imagine not being able to finish a netflix movie in 1 sitting.