[busyant]

> And yet the crisis hasn’t happened. Why is that?

I used to think this, too (and this is coming from someone who worked at an antibiotic drug-discovery startup in the early 2000s).

I think it's not that there will be a comprehensive event in which "this bacterial pathogen is now unassailable by any antibiotic in our arsenal."

It's more that, if you are on the front lines of a hospital, you'll come across many (but not all!) patients with bacterial infections for whom antibiotics won't work.

If you are an MD with enough of those types of patients, it will fuck with your decision making process. It will also cause a lot of prolonged health issues as well as death. It just won't be a wall-to-wall comprehensive type of antibiotic resistance.