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by tormeh 1273 days ago
Testing requirements are as high in other rich countries. And existing antibiotics work fine atm. Nobody’s gonna pay to use new ones unless there’s no alternative, both for cost and resistance reasons. So why bother? Might as well postpone development until there’s a real market, right?

I actually think this is good since it means we postpone usage of, and thereby resistance to, any new antibiotics.
3 comments
Retric 1273 days ago
Yes and no. Many strategies for delaying antibiotic resistance require having multiple different effective antibiotics at the same time. Thus, getting down to the point where only a few work rapidly speeds up antibiotic resistance.

Unfortunately, antibiotics are the tragedy of the commons writ large, and we’ve been wasting them for minimal gain because even minor private benefit generally outweighs long term consequences.

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mikeiz404 1273 days ago
Edit: Apparently broad spectrum antibiotics can actually lead to antimicrobial resistance [1][2]

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> I actually think this is good since it means we postpone usage of, and thereby resistance to, any new antibiotics.

This is true if you use them in isolation but I thought broad spectrum antibiotics, aka many at once, is what is typical now to slow down development of resistance? In this case you’d want to develop a few new ones and deploy them in batch.

1: https://en.m.wikipedia.org/wiki/Broad-spectrum_antibiotic

2: https://www.science.org/content/article/combining-antibiotic...

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everforward 1273 days ago
The reason not to postpone development is because it isn't a particularly quick solution. It would be one thing to develop and test them, and then postpone deployment of them. It's another thing to not have a backup plan and hope that one of the antibiotic candidates work out, and quickly.

Modern cities are a huge disease vector. That kind of population density lets sickness run rampant. Untreated TB has something like a 25% mortality rate, and we've already seen drug-resistant (DR) and extreme drug-resistant (XDR) strains of TB. An outbreak of TB that we have no antibiotics for would be devastating.

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