[dmckeon]

Also 40 years ago, 40-some years after penicillin was introduced, gonorrhea had evolved to produce an enzyme that acted specifically against it, penicillinase. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1046026/pdf/brj...

No matter how many new, different, or even radical antibiotics we develop, unless we get ahead of over-prescribing and under-treating (not taking all of a prescribed treatment course) we will continue to rapidly evolve more successful micro-organisms, to our own detriment.

[midoridensha]

I think it's utterly hopeless. With billions of humans, there's no way to get everyone to agree to do the right thing, both with doctors and especially patients. You just need a small fraction doing the wrong thing for something bad to evolve: look at Covid, for instance. That simply evolved somewhere at one point in time in one place, and then spread like wildfire.