[rdtsc]

I think you are being unfair. PyPy is something you can use on your code without modifying your code. That's a big thing. And by big I mean huge. Paying someone $70/hour to modify code is expensive. Switching "python" executable with "pypy" is a lot cheaper than profiling code then re-writing it in Cython. Yeah you might still end up having to do that but who knows, you might not have to or you might even be running faster than C (yes in theory jit compiler could do that).