[dontlaugh]

Not necessarily. Consistently indenting with tabs and aligning with spaces does work, but is tricky to enforce.

[Stratoscope]

The key to success with tabs in any language is simple: Don't use alignment.

Instead, only use indentation.

It is interesting to note that Black-formatted code uses indentation only and never uses alignment. It would be perfectly compatible with tabs, unlike Google-formatted code which relies heavily on column alignment.