[otikik]

Yes it is possible.

Main difference is that on a flat surface the dome weight is distributed across the base "automatically". If you just "copy-paste the default flat-terrain dome" on a sloped terrain, the bottom vertices might end up supporting more weight than the top ones. This might be ok for small/temporary domes. For something bigger/more permanent, you might want to "cut the sphere" in such a way that the weight distribution is as uniform as possible.

Also keep in mind that even on a flat surface geodesic domes a foundation - for example so that they don't fly away when there's strong wind. This would go double in sloped terrain.