In this thread there is a lot of both "you should use this", and "you shouldn't use this". In the end, everyone should evaluate the options for themselves and use what works best for them.
I disagree. Just today I had headache again because of a legacy jQuery-based codebase.
The jQuery version is so old, it is a security risk.
A pure JavaScript codebase updates itself with each new browser release, so to say.
So my verdict: "you shouldn't use jQuery"