If you have enough nodes to care and manually assign and at the same time don't automate deployment that sounds like an issue in general... and not with IPv6. You're likely to typo IPv4 just as well with enough entries.
Yep, but in my experience you have to manage about 2000+ machines before management will allow you to spend time on setting up deployment automation. So around the time you are setting multiple new machines a week.
Of course it is, automation is very nice, I use it for the handful of machines I have my personal stuff on. I am just saying that from my days as a sysadmin it was usually a years long uphill battle to get approval for automating even minor things.