[TwoCent]

It seems plausible that the immune system requires stressors to function well, and the absence of stressors may reduce immune system "strength". Selye's general adaptation syndrome seems applicable here as a first approximation. Muscles atrophy from disuse. Why not also immune systems?

[mprovost]

"Immunology Is Where Intuition Goes to Die"

https://www.theatlantic.com/health/archive/2020/08/covid-19-...

[trap_goes_hot]

The immune system is never dormant. It is constantly engaged. We don't live in a sterile environment, don't eat perfect sterile food, don't breathe perfect air, etc. There are multiple aspects to our immune system, and a lot of them are being stressed daily.