[tomtheelder]

The benefit is that it's extremely streamlined and simplified to suit the specific type of assets it is designed to create. It is designed for hobbyists- people creating assets for things like Minecraft and Roblox, or indie games- not for people who already know how to use something like Blender.

If you already know how to use Blender then, yes, do that.

[TazeTSchnitzel]

Even if you're familiar with Blender, there can be value in having a more focused tool. I've tried using it for low-poly 3D modelling before and it's annoying having so much of the interface dedicated to functionality I can't use.

[idlehand]

Using a limited palette has been a point of friction in Blender, too. You can't update the palette from within Blender, and you need to use tiny UV coordinates.