[brailsafe]

I use an MS sculpt keyboard and use Karabiner to swap the keys.

[dagmx]

You can swap them in the system preferences without needing extra software. At least for the modifier keys

[sofixa]

That doesn't work for key combinations such as Cmd+Tab (which only switches between applications, but not between windows of the same application) and Cmd+` (which switches between windows of the same application), you have to change them too, and some of them flat out aren't configurable out of the box, requiring third party software.