There are clinical trials on Glioblastoma CAR-T treatment but it faces the same problems as any other solid tumor - namely the solid tumor microenvironment is not amenable to the current generation of CAR-T treatments
In addition one of the dreaded side effects of CAR-T is neurotoxicity. CAR-T can cross the blood-brain barrier and leads to inflammation in the brain. You can treat it pretty quick with steroids but this side effect along with several other pro-inflammatory ones is the reason for the 30 day hospitalization sp treatment.
Not CAR-T or CRISPR AFAIK, but there's been some recent breakthroughs with getting treatments past the blood brain barrier, and promising glioblastoma treatments are in the pipeline as well. This is just what I've seen on the internet news, you'd find more than I know about it with some internet searches.
I hope you aren't affected by GBM. If you are, or someone you know is, my only advice is to live life to the fullest while you can and don't let yourself fall into denial of the prognosis.
Not me but my wife. Will just put this out there for anyone else, the advancements made in Cancer treatment in the past few years are impressive. Don't lose hope.
Also, listen to your doctors as all of the sudden everyone is oncologist. Listen to your doctors, seek second opinions, do research but question everything as there is a lot of snake oil for sale.
I'm so sorry. My mom was diagnosed a few years ago and she got preyed on by snake oil salesmen to the tune of 6 digits. The money doesn't matter to me, but people are really fucked up.
I can recommend Duke's neuro-oncology center though. They did a great job with her when Sloan Kettering wouldn't touch her.
Best of luck to the both of you and hang in there.
In addition one of the dreaded side effects of CAR-T is neurotoxicity. CAR-T can cross the blood-brain barrier and leads to inflammation in the brain. You can treat it pretty quick with steroids but this side effect along with several other pro-inflammatory ones is the reason for the 30 day hospitalization sp treatment.