There have been people with persistent itches that scratch, sometimes subconsciously, in their sleep, etc, until they hit bone or an internal organ, or both, like their brain: https://www.npr.org/2008/06/24/91852486/the-mystery-and-powe... The itch-scratch reflex is mighty powerful.
Yes indeed that was what I was thinking about, that type of case. Literally itch through your skull in the right circumstances and it sure isn't will power.