[possiblydrunk]

Effectively, you are posing a litmus test on whether someone can reasonably comment on an issue that involves virology. I think that's unfair and completely unnecessary. You don't really know anything about my background, so why are you making assumptions? I happen to have more than enough experience and knowledge in the area to make a comment. I'm not peer reviewing the work, I'm commenting on a line of argument espoused by Derek Lowe.

Derek Lowe chose to focus on defining GOF in a rather narrow way - one that can only be applied retroactively if the outcome is critical to the definition -- and uses that definition to say that criticism of the BU experiments is overblown. The general fear around experiments involving ePPP doesn't care about the exact definition of GOF. Just saying that it doesn't qualify as GOF is not going to convince people that fear it. Derek Lowe should have focused more on the points you raise in your last paragraph.

>The Omicron spike is already out there. Omicron is already out there. This isn't adding anything to SARS-CoV-2 that isn't already massively spreading in the real world, and there's no particular reason to think that this experiment will create a more deadly or transmissible virus.

Nobody intends to create a more dangerous virus on purpose. But if the outcome were so fully understood and completely predictable, then it's a waste of time and money doing the experiment just to confirm a conclusion that everyone fully agrees on and understands. And if there's little to no risk, why take precautions? Why use BSL3? Why does NIAID feel it should have been alerted? That's what Derk Lowe should have addressed, not a definition!

[DiogenesKynikos]

> Effectively, you are posing a litmus test on whether someone can reasonably comment on an issue that involves virology.

I think "understands the basics of virology" is a reasonable litmus test for who should be commenting on whether a given virology experiment is safe or not.

> Nobody intends to create a more dangerous virus on purpose.

This is not true. It's actually what the original GOF debate (focusing on influenza) was about in the 2010s.

> And if there's little to no risk, why take precautions? Why use BSL3?

Honestly? Partly to appease people like you. The scientists are being extraordinarily cautious, with a set of experiments that are highly unlikely to lead to anything particularly concerning in the first place. The danger posed by everyday people walking around with CoVID-19 is far greater than the danger posed by this experiment. Inside of labs, SARS-CoV-2 is treated like an incredibly dangerous substance. Outside of labs, people are walking into restaurants and bars and exhaling SARS-CoV-2 onto everyone around them.