[cdtwigg]

I guess I would have assumed the opposite? A virus that just jumped from bats to humans is expected to evolve pretty quickly in the binding domain as it “learns” to better target human ACE2. I thought the reason they targeted spike was that it’s on the surface of the virus and so an obvious target for antibodies to attach, whereas if you target some structural proteins deep inside the viral structure you’re taking a risk that the antibodies won’t be able to reach them.