OpenBSD's X distribution (xenocara) is based on X11R7.7 + updated components, it's just a historical naming convention. Other systems have merged X into /usr or /usr/local, OpenBSD kept the install prefix.
All of them that I can remember. Note that this is from the '90s. At some point they all merged the X stuff into /usr. Maybe it was with the x.org switch, as XFree86 does indeed mention /usr/X11R6 in the docs.
https://man.openbsd.org/hier