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> To understand why these drugs could be so revolutionary, you need to understand how obesity works—which is often different from the way it’s talked about. Many people are under the misconception that their weight can be completely controlled by diet and exercise… But researchers and doctors are more inclined to think of the condition as just that: a chronic health condition. “Our brains regulate our appetite, and they regulate our metabolism,” said Jay. For the obese, those regulations are set to retain weight. A healthy lifestyle can help prevent obesity, but when a person who’s already overweight goes on a diet, their bodies increase appetite and decrease metabolism.