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by ChrisMarshallNY
1353 days ago
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In my friend's case, it was Stage IV, before it was found. That may have had something to do with him not getting a gerbillcam until he started having symptoms. I will say his treatment wasn't fun, at all, although he'll be OK, in the long run (but chemo never leaves you the same). |
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For the chemo your friend likely experienced, this is especially true.
Colorectal cancer is often treated with the chemo cocktail, FOLFOX. The "OX" stands for oxaliplatin which causes nerve damage-- hearing loss (less than cisplatin, though), peripheral neuropathy, etc. The second half-life, in the body, of oxaliplatin is 535 months (44 years). And, the platinum remains in a reactive form.
I'd love to hear a professional chime in on if there are ways to speed the elimination. E.g., something like extended/extreme fasting (to free oxaliplatin from tissues) + sodium thiosulfate + blood plasma donation, or something?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2559818/
Some choice quotes from the link:
"The first elimination half-life (t1/2) for cisplatin was 5.02 months and the second 37.0 months. For oxaliplatin, these half-lifes were 1.37 and 535 months."
"...it was shown that Pt species in pUF were still present in a reactive form."
Edit: just submitted the above article:
https://news.ycombinator.com/item?id=33154606