[eru]

You could do statistical analysis on the mouse and keyboard inputs to try and detect this.

(Very similar to how you might detect chess cheaters, actually.)

[erwincoumans]

You can use (the data of) statistical analysis to train a deep neural network to avoid detection. That may also help avoiding chess detection cheaters, so the moves are not perfect anymore.

[eru]

Yes. You can't make cheating impossible, but you can make it harder to pull off.