Lex here, not bad for remote work, low cost of living, access to surrounding metro areas (Lou, Cinci), and Lex usually has something going on. Just got access to gigabit fiber so you're not disconnected from the rest of the world either.
Same as it ever was: most local "big" tech employers (and VCs) still hugely (and sometimes myopically, looking at you local VCs) focused on Health Insurance or are otherwise Healthcare adjacent.
But yeah, also still a lovely place for remote work, if you can get it, given the cost of living/quality of life.
Also in Lexington doing remote work - don't know too much about the local tech scene. Seems rather limited and the best option is to work remotely for a higher wage and take advantage of the lower COL in the area.
I worked for one of the big corporations in Louisville. Huge companies use lots of technologies but .NET, Java, React, SPA frameworks, Docker + Kubernetes, and cloud migrations are the norm.