[nequo]

I can think of use cases in academic research for example.

Many pieces of code run only a handful times but potentially move a lot of data. Sometimes reimplementing existing code in C/Haskell/Rust, including finding equivalent libraries, writing tests, and debugging, only because the computation turned out to be heavier than I had expected is not a good use of time. If that’s the place where I’m at, PyPy, mypyc, etc., might just do the trick.