[packetlost]

My understanding is ARM has less strict memory (ordering) guarantees, as well as the inability to explicitly trigger cache line flushes from user-space. That being said, I imagine most of the optimizations would come from the particular aspects of the GPU/graphics pipeline, which I imagine is substantially different from the standard PC structure.

[TillE]

Yeah you can always cut corners with the GPU if you have to, but Factorio has the large problem of making a CPU-intensive deterministic simulation run at 60 Hz.

Thinking about it some more, there are also probably some tweaks you could use for situations with limited resources which wouldn't apply to most PCs, but would affect the Switch.