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by tostonescon 1381 days ago
The ba.4/ba.5 is not the first bivalent mRNA vaccine. The ba.1 bivalent vaccine was the first, which has been studied in a larger population than the ba.4/5 bivalent vaccine.

The FDA instructed Pfizer and moderna to reformulate based on the changing variant landscape as ba.4/5 overtook ba.1

The ba.4/5 bivalent vaccine was an extremely incremental change from the ba.1 booster