[icegreentea2]

There are a variety of inflammation pathways and signalling proteins. It's possible that IL-8beta has a uniquely high cancer inducing potential, and that when blocked, other signalling proteins can still generate appropriate inflammation for proper function.

But ya, long-term effects are going to have to be studied. Luckily, it looks like IL-8b inhibitors are used to treat other chronic diseases, so we can pull some data out of there (though a lot of them are auto-immune, so the validity of extrapolating to a more healthy population is maybe questionable).

It's also possible that we can develop a more precise approach that moderates the signalling response of IL-8beta without fully suppressing it.