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by notch656a 1375 days ago
How much was Hoffman working with though? The absorptivity needn't be high when the potency is so high.
1 comments

From LSD - My Problem Child, pt. "Discovery of the Psychic Effects of LSD":

"Nevertheless, in the spring of 1943, I repeated the synthesis of LSD-25. As in the first synthesis, this involved the production of only a few centigrams of the compound."

"In the final step of the synthesis, during the purification and crystallization of lysergic acid diethylamide in the form of a tartrate (tartaric acid salt), I was interrupted in my work by unusual sensations."

...

"But this led to another question: how had I managed to absorb this material? Because of the known toxicity of ergot substances, I always maintained meticulously neat work habits. Possibly a bit of the LSD solution had contacted my fingertips during crystallization, and a trace of the substance was absorbed through the skin. If LSD-25 had indeed been the cause of this bizarre experience, then it must be a substance of extraordinary potency."

Enjoyed the excerpts and thank you!

I take a few to mean more than 2 centigrams. So 30mg minimum. Thats 300x the 'normal' dose.

so Hoffman doesn't actually know how he absorbed it

>Possibly a bit of the LSD solution had contacted my fingertips during crystallization, and a trace of the substance was absorbed through the skin.

that's a possibly, I suppose if that possibly exists then possibly some got on object X and then after leaving lab object X came in contact with his mouth or even nose when he touched his face.