[r_hoods_ghost]

Hands down the best implementation of shortcuts I've come across is Blender (the 3d modeller). First it has shortcuts for many actions out of the box and second you can create or modify any keyboard shortcuts on (almost) any operator (button) in the interface by right clicking on the operator and assigning your shortcuts. There is also a fully searchable and customisable key map, you can import and export key maps and you can switch between them easily. Lastly it supports search based navigation.