[kaba0]

It’s not actually hardcoded, but you would have to compile everything from scratch as the hash would depend on that as well, throwing out the whole binary cache.

[wmertens]

Actually, there's quite a few hard-coded references to /nix in nixpkgs I believe. It's possible but a little more work than just changing the prefix.

[grhmc]

There may be, but at least one BigCorp deploys Nix to a different prefix.