How is it neutering it? Can you specifically list the features that would not be possible under MV3, and how commonly used said features are by the average people who install the extension and don't customize anything?
You can follow the issue tracker for any progress related to MV3 development of uBO but from what I can see, there isn't much interest yet in porting uBO to MV3 because it's not worth it.
This EFF article also goes into details about why MV3 is harmful for adblockers.
That comment you link is from 2019, and Google has made many substantial changes to MV3 since in response to the feedback. It obviously still doesn't give as much power as WebRequest API, but they still addressed many complaints and increased a lot of the limits.
The EFF article is pretty recent and it doesn't look good either. I haven't come across ongoing work for a port of uBO to MV3. If there isn't, that says a lot as well.
Whatever MV3 may offer, I for one do not want adblockers to be compromised. If anything, they should be more powerful rather than less. Hypothetically and optimistically speaking, even if a MV3 port of uBO offers 80% of the current functionally, it would still be detrimental for browsing the "modern" web.
https://github.com/uBlockOrigin/uBlock-issues/issues/338#iss...
You can follow the issue tracker for any progress related to MV3 development of uBO but from what I can see, there isn't much interest yet in porting uBO to MV3 because it's not worth it.
This EFF article also goes into details about why MV3 is harmful for adblockers.
https://www.eff.org/deeplinks/2021/12/googles-manifest-v3-st...