[kortex]

Chlorine-carbon (or halocarbons in general) bonds are somewhat rare in nature. That is not to say they don't exist, but they are a bit unusual. The problem with halocarbons (aside from fluorine, which has its own issues) is they are generally not very reactive, so they can bioaccumulate. But when they do react with biological systems, it tends to be in unwanted and toxic ways.

That said, as a former chemist, I consume sucralose, and I am not worried by it. Unlike most halocarbons, It's very water soluble, so it does not react in the ways the bad halocarbons do.