[garganzol]

This is relatively well known [1]. ROS normally go away after sleeping, and this one of the reasons we need sleep.

But. If you are past a certain threshold, ROS can do so much damage that it starts to affect cellular ATP production, leading to a tissue hypoxia. When this happens, it leads to onset of an acquired mitochondrial dysfunction. This is a pathological state that is characterized by a lingering fatigue as its main hallmark sign. Such fatigue does not go away after sleeping.

But usually it is not like 0 or 1. A person may have something in between and live without even knowing it, thinking that it's all just mental or age-related.

[1] https://pubmed.ncbi.nlm.nih.gov/27285492/

[copperx]

I wish I had heard about this earlier. I'm now 40 and my sleep patterns are not healthy. I don't have insomnia, I'm just used to sleeping past the point of total exhaustion. That cannot be good given what you say about ROS :(