Probably not worth it. Not trying to be dismissive but genuinely, it's fine to have side effects and if it saves 1000 hrs of engineering over the life cycle of a project I'd wager it's completely worth it.
The keypoint here is that nix requires a larger up front investment. But once done it will save you 1000 hrs of engineering in the long run. It's absolutely faster to start a project without nix and just start coding. But once you have many deps, multiple developers, ci, multiple environments nix becomes a no brainer.