[Traubenfuchs]

> nobody can explain how they could ever be permanent

Epigenetic changes. Easy as that.

I am not about to argue if PFS is real though. I haven‘t formed my opinion on that and probably never will, because one can‘t prove it doesn‘t exist, unfortunately.

For me it‘s serious side effects were completely transient.

[auganov]

Epigenetics are interesting, but is finasteride's epigentic action uniquely interesting? Not too familiar with the latest on epigenetics, but a few quick Google searches suggest nearly every heavily-researched drug produces some kind of an epigenetic effect.

I don't think it's impossible something is going on. I just feel like in the realm of medical controversies it's one of the least substantial. Even if some lasting physical effect can be proven, it's still a long way from there to lasting mental anguish.

How convinced are you it caused your depression? Did you try taking it again?