[7thaccount]

Based on my digging around, I think Rebol was really good for GUI stuff back in the day as there are hundreds of cool examples of things like Tetris in like 1/4 page of code. Delphi was supposedly really good as well in the 90s when people used it for all kinds of desktop apps. VB6 might be in there as well. Matlab makes this all pretty easy as well if you have a license as it has a form designer and just makes it really easy to do that kind of stuff. C# has Winforms and other stuff to build extremely detailed and complex GUIs, but it's not as simple as Matlab for sure. Tcl has a very common library called Tk that can do a lot of simple GUI work like if you want a button on a form, but it didn't seem to be a good bet for scientific work when I checked. There's a toolkit for Pharo Smalltalk that can do really cool graphics stuff, but Smalltalk is pretty niche in a lot of ways. Python has a bunch of GUI toolkits, but none of them seem very good. Java and languages on the JVM can use some of those toolkits like "Swing", but I don't find it very intuitive. 8th has a built-in native GUI, but it's mainly useful for buttons and drop-downs I think. Mathematica surprisingly has a pretty decent GUI setup in their Notebooks as well as advanced shoot for graphics.