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by mtlmtlmtlmtl
1429 days ago
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Pseudo-opioid sounds right to me. Typically opioids are agonists at MOR, i.e activate the receptor on their own. Whereas a PAM binds to a separate binding site, and increases the effect of binding by the endogenous neurotransmitter(hence it positively modulates it). How the increased effect actually happens depends on the receptor and can get pretty complicated so I won't go into it since I'd have to google quite a bit. |
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