[zamberzand]

Trans woman here, here are my thoughts:

So, research into the impact of biological sex on medication, and similar, doesn't really seem alienating to me. Despite the existence of trans people, there are obviously two main categories that people fall into in a medical sense.

That said, I do think it would be a mistake to assume that the conclusions of any research into biological sex can be directly extrapolated to trans people. If we know that the relevant mechanism is hormones or chromosomes we may be able to predict effects on trans people--but we also might not be able to, if the mechanism isn't known, or for whatever other reason.

One well known example is that trans women's risk of breast cancer is more comparable to cis women than cis men. If I recall correctly, this is because the relevant factors are basically whether a person has breasts or not, and of course, trans women grow breasts when on estrogen.