[wtetzner]

> (some) reasons behind the longevity of many of those centenarians have been identified: low mTOR activity and high omega 3 intake.

I wonder how true this is, given that carbs trigger mTOR harder and longer than protein, and the Mediterranean diet seems pretty high-carb.

In any case, if you're worried about mTOR, intermittent fasting is probably the simplest life-style change you can make.

[arboghast]

Never heard of that. References?

Either way, I agree that IF is the best inhibitor of mTOR. My guess is that there is much we don’t know still about the effects of Rapamycin and mTOR itself. Clearly mTOR inhibition extends lifespan considerably in mammals, but we also know that protein intake is crucial to retain muscle mass in old age. Seems like a double edged sword. Question is, using rapamycin, can you still consume adequate protein amounts and retain muscle mass?