[orangepurple]

To expand upon this, Cholesterol is wrapped in lipoprotein, and pathogenesis is caused by malfunction of lipoproteins due to proximal oxidative and inflammatory effects upon them.

[tpush]

> [...] due to proximal oxidative and inflammatory effects upon them.

No, this is not true.

[orangepurple]

It absolutely is true for many reasons; one of them is uptake of ox-LDL by macrophage and their conversion into foam cells.

More info: https://www.ncbi.nlm.nih.gov/books/NBK326741/

Additionally, ApoB is an excellent biomarker of cardiovascular health risk.

[tpush]

I agree with ApoB being the marker for CVD risk. What I'm disagreeing with is the statement that pathogenesis is caused by inflammation and/or oxidization; instead I'd say it's the number of particles that's the primary cause, with the rest of the mechanism following.

Might just be semantic quibbling, though.

[kelp]

So what’s the cause of high cholesterol and how do you lower it?

[theNJR]

Buckle up

https://peterattiamd.com/why-there-is-no-bad-or-good-cholest...

[justin66]

https://www.mayoclinic.org/diseases-conditions/high-blood-ch...